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Nat Commun 16 , 5547 (2025)

Given the limitations of patient derived cell models, to further test the translational impact of our findings we applied our recently reported approach of treating acute slice cultures of human glioma surgical specimens with drugs and deconvolving cell type-specific responses with scRNA-seq (Zhao et al, 2021)

Vitamin B12 Deficiency Symptoms Recognizing the B12 deficiency symptoms is important for early intervention: Fatigue and weakness Pale or jaundiced skin Numbness or tingling in hands and feet Difficulty walking or balance problems Sore mouth or tongue Cognitive issues like memory loss or confusion Diagnosis of Vitamin B12 Deficiency Diagnosing vitamin B12 deficiency involves several steps: Assessment of Symptoms: The physician will ask about your medical history and look for signs like fatigue, weakness, pale skin, shortness of breath, numbness or tingling in hands and feet, difficulty walking, memory problems, or changes in behavior

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