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Using chemical inhibitors to block GCLC in animals leads to inconsistent and incomplete loss of GSH across tissues 19

The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae

Similar findings were recently reported in primary renal proximal tubular cells from uninephrotectomized rats ( Xenopus laevis oocytes microinjected with the DIC cRNA from rat liver did not result in significant GSH transport activity (Martensson et al., 1990)

46 This may be attributed to mtROS-mediated oxidation of succinate dehydrogenase, stabilizing hypoxia-inducible factor 1-alpha (HIF-1) and subsequently driving sustained IL-1 expression