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During states of increased systemic inflammation, such as sepsis or trauma, the brain experiences a mismatch between energy supply and demand, which is commonly associated with delirium in those with preexisting cognitive impairment [3]

Genotyping was performed with oligos flanking the guide binding sites to identify mutants that lack the entire region between the crRNA target sites

A summary of suggested mechanisms of action of environmental chemicals on DNA methylation machinery is shown in Figure 1