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Absorption, distribution, metabolism, and excretion of [(14)C]-Sotorasib in rats and dogs: interspecies differences in absorption, protein conjugation and metabolism

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94 Experimental and clinical research has substantiated that elevated uric acid levels exert detrimental effects on cardiovascular health, with increased oxidative stress being a key mechanism implicated in these adverse outcomes, 6,66 decreased nitric oxide availability, endothelial dysfunction, the promotion of local and systemic inflammation, vasoconstriction, vascular smooth muscle cell proliferation, insulin resistance 309 and metabolic disorder