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Although the [U- 13 C]glucose isotope-labeling assay showed slightly increased incorporation of [ 13 C]glucose-derived carbons into glutamate (Figure 3A), -ketoglutarate (-KG) (Figure 3C), and GSH (Figure 3E) as well as GSSG (Figure 3G), the relative levels of overall glutamate (Figure 3B), -KG (Figure 3D), and GSH (Figure 3F) among all detected metabolites decreased

The relative contribution of these two metabolic pathways remains a subject of ongoing debate

The investigations on in vitro BBB or BCB models, analogous to those published by Mller et al