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Mutant supernatant fractions also contained several amino acid derivatives with known antioxidant and anti-melanogenic properties, including a 150-fold relative increase in hydroxytyrosol 49

Furthermore, before considering SQOR-based therapies, it will be necessary to develop companion diagnostic tools to assess SQOR activity in a patients tissues and determine how dependent cell survival is on SQOR, thereby guiding whether to inhibit or activate SQOR to achieve the desired therapeutic outcome

However, current in vitro models fail to fully replicate in vivo microenvironment features such as BBB disruption and immune cell infiltration

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