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10.1016/j.phrs.2019.04.010 42 DuZ.WangJ.LuY.MaX.WenR.LinJ.et al (2020)

Clinical trials of drugs targeting amino acid metabolism This review synthesizes evidence underscoring a paradigm shift in our understanding of amino acids, recasting them from passive nutrients to active governors of the hepatic microenvironment

Reprogrammed proline metabolism supports HCC proliferation and confers drug resistance

Furthermore, the high electron density of the Ru centers optimizes the binding strength of oxygen species and enhances resistance to H 2 O 2 toxicity in Ru-hydroxide