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The activated PERK-eIF2 signaling pathway plays a significant role in mediating inflammation through translational arrest, which reduces the levels of IB, leading to the activation of NF-B [80, 81]

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6770 Dal Negro and colleagues evaluated the effect of nebulized tobramycin (300 mg twice daily for 2 weeks) on the incidence of exacerbations and proinflammatory markers in patients with severe to very severe COPD who were colonized with Pseudomonas aeruginosa