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Additionally, HDAC6 inhibitors activate redox-regulating proteins like peroxiredoxins (reduce ROS) and support the function of the autophagy and ubiquitin-proteasome system (UPS) (both are impaired in PD patients) 62

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By inhibiting the opening of the mitochondrial permeability transition pore, -viniferin prevents rapid influx of solutes and water into the matrix, thereby maintaining cristae integrity and sustaining ATP synthesis via oxidative phosphorylation (Zhang et al

Its expression is dependent on selenium metabolism and the mevalonate pathway, which generates the isopentenyl pyrophosphate required for the maturation of the selenocysteine tRNA essential for the incorporation of Sec into its catalytic site (4547)