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The DIO mice were randomized into three treatment groups balanced by baseline body weight and body composition (fat and lean mass) measures

While IGF-1 has important physiological functions, elevated levels carry potential concerns including increased cell proliferation that may support tumor growth in individuals with cancer or pre-cancerous conditions, accelerated aging processes through growth pathway activation, potential cardiovascular effects with chronic elevation, and metabolic consequences including effects on glucose and lipid metabolism

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Wolffenbuttel BHR, Wouters H, de Jong WHA, Huls G, van der Klauw MM