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Furthermore, from 2010 to 2021, the 'age-standardized disability-adjusted life-years' for MDD increased by 16.4% [4]

108,109 The decrease in mitochondrial membrane potential induces PINK1 aggregation and autophosphorylation on the outer mitochondrial membrane, which recruits Parkin to initiate the PINK1-Parkin mitophagy pathway to remove damaged mitochondria

FIGURE 4 Evidence suggests that aged animals are more susceptible to RGCs loss in models of acute IOP elevation-induced ischemia, optic nerve crush, or laser-induced ocular hypertension (Tan et al., 2015