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Data analysis NMR spectra were apodized (0.5 Hz), Fourier transformed, followed by phase and baseline correction in iNMR 3.6 (Mestrelab)

Collectively, these findings illustrate an intricate network in which copper ions modulate cell fate by targeting multiple nodes of the ferroptotic pathway, presenting a promising avenue for therapeutic interventions

A receptor is linked to a chloride channel

On the other hand, the combination of immune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 inhibitors, with ferroptosis inducers has been shown to significantly enhance therapeutic efficacy, particularly in ferroptosis-sensitive tumor cells (46)