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Lelle, M

Molecular mechanisms underlying vascular remodeling in hypertension

Rhein, one of the anthraquinone ingredients in the root of rhubarb, inhibits the phosphorylation of PI3K/AKT/FOXO3a, resulting in sustained high levels of Bim expression, which ultimately induces caspase cleavage and apoptosis [163]

Stimulation with 6-hydroxydopamine (6-OHDA) markedly downregulates nuclear factor erythroid 2related factor 2 (NRF2) expression in PC-12 cells, elevates Fe 2+ and reactive oxygen species (ROS) levels, suppresses glutathione peroxidase 4 (GPX4), promotes both ferroptosis and apoptosis, inhibits cell proliferation, and causes neuronal damage