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An emerging theme for neurodevelopmental disorders such as MCD, is that the disruption of metabolic regulation can drive pathological cellular phenotypes, and may integrate with signaling pathways such as mTOR, AMPK, and PI3K/AKT to sustain these phenotypes ( Macromolecules such as carbohydrates, lipids, and amino acids are crucial for providing energy substrates for cortical development (Figure 4)

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