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Intestinal disorders and the loss of gut microbiota diversity impair the integrity of the intestinal barrier and can allow harmful microbial products, such as lipopolysaccharides, to enter the bloodstream, leading to systemic inflammation and metabolic disorders, which can weaken muscle function and reduce muscle mass (91) (Figure 3)

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To further confirm that the endogenous carnitine shuttle provides an acetyl-CoA pool that can be used for histone acetylation, we conducted 13 C 6 -glucose tracing in cells with knockdown of the carnitine acetyltransferases CrAT and CrOT

Mara Snchez es una estudiante de periodismo bilinge de la Universidad Carlos III de Madrid