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Introduction Obesity, a multifactorial relapsing chronic disease attributed to the complicated interaction of behavioral, environmental, and genetic factors ( In this context, L-carnitine, a conditionally essential nutrient ( Furthermore, the crucial role of gut microbiota dysbiosis as an underlying driver of obesity has attracted great concern ( According to literature, multistrain synbiotics are reported to be more beneficial in modulating gut microbiota than single-strain synbiotics or pro/prebiotics individual therapy ( As mentioned, current data indicate the putative efficacy of both L-carnitine ( Materials and methods Study design and participants In this double-blind, controlled, randomized clinical trial (RCT), implemented between February and August 2019 at the Nutrition Research Center, Tabriz University of Medical Sciences (TBZMED, Tabriz, Iran), 46 eligible volunteer women with obesity, unwilling to follow weight-reducing diets, aged 1949 years, and body mass index (BMI) of 3035 kg/m 2 were recruited through announcement and prescreened for enrollment via phone interview