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Neurology 98 , 3143 (2022)

doi: 10.1038/NATURE06908, 223

The results indicated that GSTM2 regulated SREBF1 and PLIN2 expression by affecting ASK1 activity

The observed decrease in glutamic acid aligns with abnormalities in amino acid metabolism, the urea cycle, the glucosealanine cycle, glutathione biosynthesis, and the malateaspartate shuttle in male patients, regardless of the specific PD-linked mutation ( Fig