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The role of thiopurines in reducing the need for surgical resection in Crohns disease: a systematic review and meta-analysis

Stepanova et al., 2022)

IGF1R deficiency reduces tumor growth, proliferation, inflammation and vascularization, and increases apoptosis after tumor heterotopic transplantation Since IGF1R has been implicated in the pathogenesis of lung cancer by facilitating metastasis, tumor-associated inflammation and immune checkpoint regulation [12, 16], we decided to assess whether IGF1R deficiency in the TME delays implantation and progression in a heterotopic LLC mouse model