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While this chemotherapy regimen demonstrates favorable response rates in most patients, the emergence of drug resistance remains a primary challenge ( In this review, we firstly described the cellular and molecular mechanisms involved in drug resistance in HGSOC, and summarized the novel diagnostic and therapeutic strategies for detection and treatment of drug resistance in HGSOC, shedding light on the future pre-clinical and clinical investigations targeting HGSOC

Nat Aging 4:110128 Yang Q, Cong L, Wang Y, Luo X, Li H, Wang H, Zhu J, Dai S, Jin H, Yao G et al (2020) Increasing ovarian NAD(+) levels improve mitochondrial functions and reverse ovarian aging