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Using Immunofluorescence techniques, the authors were able to show that macrophages that expressed mincle entered the damaged kidney on the third day after cisplatin was introduced

In fact, reactive oxygen species (ROS) and peroxides (H2O2) upregulate the transsulfuration pathway (homocysteine towards cysteine and eventually the GSH-Px system) and downregulate the transmethylation (homocysteine towards methionine) (Figure 3)