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doi: 10.1016/j.cell.2020.01.021 334 StremmelC.SchuchertR.WagnerF.ThalerR.WeinbergerT.PickR.et al

Unbound iron enters the cardiomyocytes through the L-type calcium channels ( The fact that cardiomyocyte iron overload is a storage problem and not an infiltrative process indicates that iron can be removed to reverse cardiac iron overload and associated damage ( Molecular mechanism of myocardial injury caused by cardiac iron overload in thalassemia Iron overload is a common feature in patients with -thalassemia, but the molecular mechanism of cardiac damage caused by iron overload in thalassemia is poorly understood

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