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+ Glucose-6-phosphate dehydrogenase Glucose-6-phosphate dehydrogenase ( G6PD or G6PDH ) (EC 1.1.1.49) is a cytosolic enzyme that catalyzes the chemical reaction: [1] This enzyme participates in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the reduced form of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH)

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