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More importantly, the regeneration of glycocalyx through endothelial cell synthesis of glycosaminoglycans (GAGs) and shear stress-driven SDC recycling provides therapeutic prospects

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The observed regioselectivity is consistent with the known directing effect of the indole nitrogen and C7-borylation of 2,3-disubstituted indoles 49,50

The shift in the composition of KCs from a pro-inflammatory phenotype (higher M1/M2 ratio) in the CDG group to a less inflammatory phenotype (lower M1/M2 ratio) in the CDVDG group likely contributed to the improved hepatic cytokine profile observed in the latter