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Intratumor injection of Clostridium histolyticum spores and intravenous injection of Clostridium perfringens spores lead to lysis of tumor tissues without adverse effects on normal tissue (Kubiak and Minton, 2015)

Increased iron loss in the menstrual blood and inadequate dietary iron intake have been suggested to contribute to a higher prevalence of anemia in girls 33,48

Rao PL, et al

The excessive buildup of ECM components, such as collagen, fibronectin, laminin, glycoproteins, proteoglycans, and various polysaccharides, in the tubulointerstitial space during fibrosis progression disrupt kidney structure, reduce blood supply, and impair renal function, which ultimately leads to irreversible kidney failure [7]