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These findings highlight the dysbiosis of the gut microbiota and dysregulation of microbial metabolites in CKD ( Figure 2 )

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Dysregulation in disease: Dysregulation of the HMP shunt has been implicated in a variety of diseases, including cancer, metabolic disorders, and neurodegenerative diseases

Initially, glucose binds to free amino groups in molecules such as proteins, forming Schiff bases, which then rearrange into Amadori products