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In fact, the treatment induced changes in only six metabolites that were independent of the genotype, namely, citrate, acetate, aspartate, ethanolamine, formate, and fumarate (Fig S6)

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Therefore, systematically elucidating the regulatory networks, functional impacts, and clinicaltranslation potential of lactylation in HCC holds significant theoretical and practical importance for developing novel therapeutic strategies and improving patient outcomes (127)