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In the catalytic cycle of GPX4, the -SeH (the main active group of GPX4) is oxidized by the PLOOH to selenic acid (-SeOH), while G-SH can reduce -SeOH and further activates GPX4, releasing GS-SG to prevent GPX4 from being inactivated (Ingold et al., 2018)

Better understanding of the underlying molecular processes leading to gradual oxidation and also the downstream processes involved in signal transduction cascades enabling the plant to adapt to a stress situation requires the ability to measure individual components of the cellular redox buffer system in a dynamic way

Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line

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