The skin predominantly contains -, -, -carotene lutein, zeaxanthin, lycopene, and their isomers as the main forms of carotenoids (111, 112)
On one hand, intracellular labile iron overload caused by iron homeostasis imbalance exacerbates oxidative stress ( Significant progress has been made in prevention and treatment strategies in recent years, particularly through lifestyle interventions such as regular physical activity ( This review aims to: First, integrate multidimensional pathogenesisgoing beyond traditional frameworks to include lipid metabolism disorders, chronic inflammation, immune responses, cellular senescence, epigenetic regulation, vascular calcification, and metabolic abnormalities (e.g., iron, phosphate)and construct a more holistic molecular network
*Correspondence: Qingfeng Zhai, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Here, such difficulties are overcome through re-bridging of the inter-chain disulfides of cetuximab (CTX) with auristatin-bearing pyridazinediones, to yield a highly refined anti-epidermal growth factor receptor (EGFR) ADC
