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Although the exact reasons are not known, we hypothesize that this could be an effect of the increased density and stiffness of the material, both of which have been shown in previous studies to have potentially detrimental impacts upon cellular migration and axonal elongation across nerve gaps 32,33,35,36,37

Moreover, iron is part of the prosthetic group of catalases, key antioxidant enzymes that counteract oxidative stress by catalyzing the reduction and detoxification of hydrogen peroxide

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