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Data processing All data obtained from the four assays with the two systems were processed with software (Progenesis QI 3.0.3.0, Nonlinear Dynamic, Newcastle, UK) for peak picking, alignment, and normalization to produce peak intensities for retention time ( t R ) and mass-to-charge ratio ( m/z ) data pairs

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Therefore, there remains a major unmet need for alternative model systems, which are more relevant to humans and which can provide improved prediction of risk of liver injury in humans