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Silymarin: A Review of its Clinical Properties in the Management of Hepatic Disorders Keri Wellington Blair Jarvis The mechanisms of action of silymarin involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as -amanitin

10.1002/1878-0261.13079 32 GaoX.HuangH.PanC.MeiZ.YinS.ZhouL.et al (2022)

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Sudlow and colleagues first described the most important drug-binding sites in 1975, after identifying two specific locations in subdomains IIA and IIIA based on patterns of fluorescent probe displacement by competitive drugs.18, 19 Albumin also possesses esterase capability, allowing it to hydrolyse ester bonds of bound drugs and subsequently modify their pharmacological effects