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The Journal of hand surgery 33:102112 Kang EA, Han YM, An JM, Park YJ, Sikiric P, Kim DH, Kwon KA, Kim YJ, Yang D, Tchah H, Hahm KB (2018) BPC157 as potential agent rescuing from cancer cachexia

doi: 10.1111/j.1360-0443.1993.tb02093.x 27 SedgwickJ

NAD levels naturally decline with age and can also be reduced by stress, illness, poor sleep, intense exercise, and inadequate nutrition, which may contribute to fatigue, cognitive changes, and reduced resilience