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Whilst the NHS notes that taking up to 2,000 micrograms daily is unlikely to cause harm in most people, there is generally no benefit to consuming such excessive amounts unless treating confirmed deficiency under medical supervision

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The study examined safety parameters and metabolic biomarkers over a 12-week treatment period [2]

Medications that reduce stomach acid, such as proton pump inhibitors (PPIs) and H2-receptor antagonists, can impair the absorption of dietary B12, making high-dose liquid supplementation even more critical for patients on these drugs