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Polymeric NPs have been showing great and interesting results as skin delivery systems to improve the bioavailability of the different compounds, either by enhancing drug absorption/penetration and preventing early drug degradation, or as a method to control drug release (Abdel-Hafez et al

There are no changes to the estimated submission burden per response due to the policies finalized in section IV.A.4

However, it is still unsure what are the differences in metabolism of hyperuricemia and gout and whether these differences could affect acute gouty attacks

Genetic variations can affect drug metabolism, leading to an induced risk of hepatotoxicity