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10.1371/journal.pone.0124844 PLoS One Summary Keywords long-chain acylcarnitines, metabolomics, cardiac pathophysiology, electrophysiology, arrhythmias, excitation-contraction coupling, calcium Citation Aitken-Buck HM, Krause J, Zeller T, Jones PP and Lamberts RR (2020) Long-Chain Acylcarnitines and Cardiac Excitation-Contraction Coupling: Links to Arrhythmias

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Many studies show that berberine can significantly lower blood sugar levels in people with type 2 diabetes ( decrease insulin resistance, making the blood sugar-lowering hormone insulin more effective increase glycolysis, helping your body break down sugars inside cells decrease sugar production in your liver slow the breakdown of carbohydrates in your gut increase the number of beneficial bacteria in your gut In a 2008 study of 116 people with diabetes, taking 1 gram of berberine per day lowered fasting blood sugar by 20% ( It also lowered hemoglobin A1c (HbA1c), a marker of long-term blood sugar regulation, by 12% and improved levels of blood lipids such as cholesterol and triglycerides ( According to an older review of 14 studies, berberine may be as effective as certain oral diabetes drugs, including metformin, glipizide, and rosiglitazone ( It works very well in combination with lifestyle changes and has additive effects when used with other blood sugar-lowering drugs ( Summary Berberine has been shown to help lower blood sugar and HbA1c

DRP1 deficiency impairs mitochondrial fission, which results in elongated mitochondria and has been linked to reduced oxidative phosphorylation capacity and suppressed PGC-1 signaling