*Correspondence: Menghua Dai [email protected] Zhao [email protected] This article was submitted to Gastrointestinal Cancers, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Heres what the research has to say about CoQ10s most well-known mechanisms of action: Antioxidant and anti-inflammatory activity CoQ10 works as an antioxidant, dramatically reducing markers of inflammation and oxidative stress in numerous tissues and systems across dozens of clinical studies.41 In addition, CoQ10 has also been shown to help recycle and regenerate other antioxidants, including tocopherol and ascorbate.42 On the inflammation side, an umbrella review (essentially a meta-analysis of meta-analyses) discusses the coenzymes ability to mitigate inflammation by modulating NF-kB-related pathways, while a single targeted study in rats revealed a connection to both NF-kB pathways and Nr-f2 pathways (both instigate inflammation in response to certain stimuli, such as exercise).43 44 Mitochondrial health CoQ10 has a central role to play in the electron transport chain, shuttling both electrons and protons in the process by which mitochondria produce adenosine triphosphate (ATP).42 Mitochondria also store CoQ10 for use in numerous critical pathways beyond just ATP, including fatty acid -oxidation and the metabolism of glycine, arginine, proline, glyoxylate, and sulfide oxidation.45 Together, these mechanisms allow CoQ10 to influence multiple aspects of mitochondrial health and activity
doi: 10.2147/COPD.S54477 58 FulteSAttoBMcCartyAHornKJRedzicJSEisenmesserEet al
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