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Description

L-

Goldstein and colleagues described it as a component of the thymosin fraction from calf thymus, and later work demonstrated its ubiquitous expression in nucleated mammalian cells and high concentration in platelets [1]

This mechanism plays a crucial role in tissue regeneration and wound healing

By taking advantage of the cytoplasmic transmitochondrial hybrid (cybrid) cell model [46], it has been demonstrated that oestrogens reduce ROS production and limit apoptotic cell death by activating mitochondrial biogenesis in cells carrying LHON mutations, improving the metabolic defect [47]