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Adjuvant paclitaxel and trastuzumab for node-negative, HER2positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial

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In parallel, causal in vivo studies targeting key structural regulators of these contact sites, such as MFN2 and other tethering proteins, will be particularly informative for determining whether disruption of organelle interaction hubs directly contributes to mitochondrial dysfunction, metabolic imbalance, and functional ovarian decline