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2.2.3 Autophagy and apoptosis Autophagy is an early cellular response to METH-induced stress and is activated by the mTOR signaling pathway (Xu et al., 2018) (Figure 1)

Methods: We conducted a cross-sectional study in which outpatients with DC completed assessments of quality of life (Short-Form Liver Disease Quality of Life scale, SF-LDQOL, range 0-100, higher scores=higher QOL), symptom burden (Revised Edmonton Symptom Assessment Scale, ESAS-r), depression (Patient Health Questionnaire 9, PHQ-9) and anxiety symptoms (Hospital Anxiety and Depression Scale, HADS-A)

Once bound, these toxins become water-soluble and can be transported out of cells

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