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Palmns et al, 2014

Cystine limitation induced the expression of AARE-containing genes in the ISR, which are involved in amino acid metabolism ( SLC7A11 , SLC7A1 and SLC38A2 ) and cell survival ( TRIB3 ) (Fig

Further efforts are required to comprehensively investigate and understand the reactivity profiles across diverse warhead classes, thus enabling more informed and systematic optimization approaches

Knowledge of these agents and their pharmacology, their indications, correct dosification, patients risk factors for central nervous system bleeding, and their treatment, either medical with the specific reversal of the anticoagulant agent involvedwhen availableor surgical if it is necessary, are the most important interventions in the management of this complication