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Such iron overload is particularly apt to occur in patients with hemoglobinopathies and other refractory anemias that might be erroneously diagnosed as iron deficiency anemias

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Given the important role of humoral immunity in the development of CTD-ILD as signified by the association of certain antibodies with the development of ILD, it was hypothesized that rituximab, an anti-CD20 antibody that depletes B-cells (74), would have a beneficial effect for the treatment of CTD-ILD

Elevated homocysteine levels can lead to vascular complications, increasing the risk for atherosclerosis and heart disease