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Taking berberine with or after meals rather than on an empty stomach may improve gastrointestinal tolerance

Separately, RegeneRx's ophthalmic formulation RGN-259 completed Phase 3 trials (ARISE-1 and ARISE-2) for dry eye with mixed results

In the myb4 hy5 double mutant, CHS expression was similar to the hy5 mutant, indicating that HY5 acts downstream of MYB4 in regulating CHS expression under control condition ( Figures 6E, F )