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10,278 Genetic suppression of the IKK/NF-B pathway, achieved through the deletion of one p65 allele, or pharmacological intervention via IKK inhibitors, such as 8K-NBD, has been shown to delay the onset and mitigate the severity of aging symptoms and age-related pathologies in the nervous system of murine models 10,279

The likelihood of pre-existing resistant clones is shaped by tumor size, baseline mutational burden, fitness costs, and microenvironmental constraints, making therapeutic failure an expected evolutionary outcome under strong selective pressure

4c, d) and observed their effects on tumor progression

Langille JJ