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For the comparison of PLC versus placebo, there was a high level of both clinical and statistical heterogeneity due to study size, participants coming from different countries and centers, the combination of participants with and without diabetes, and the use of different treadmill protocols

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Paraffin sections were stained using the AB-PAS method and then examined and quantified for goblet cells under a microscope ( TABLE 2 Scoring criteria for histological changes

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