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[8] Schulze and Winterstein synthesized arginine from ornithine and cyanamide in 1899, [9] but some doubts about arginine's structure lingered [10] until Srensen's synthesis of 1910

PLoS ONE 11(7):e0158779 Reddy DS (2023) Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies

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In the alternative pathway, StARD1, a mitochondrial cholesterol transporter, and CYP27A1 limit mitochondrial oxysterol synthesis