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Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1

Hyperhomocysteinemia is observed in approximately 5% of the general population and is associated with increased risk for many inflammatory disorders including auto immune disorders (Rheumatoid Arthritis, Diabetes, Multiple Sclerosis, Systemic Lupus erythematosus, Grave disease), birth defects and adverse pregnancy outcomes (pre-eclampsia, placental abruption, spontaneous abortion, low birth weight), vascular and neurodegenerative diseases

Methotrexate is a DMARD used for rheumatoid arthritis and psoriatic conditions, requiring weekly dosing and regular blood monitoring of liver, kidney, and blood count function

Li Q, Wang C, Mou Z