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Niacinamide (vitamin B3, technically not peptide but frequently combined in peptide formulations ) addresses pigmented dark circles through multiple mechanisms including inhibiting melanosome transfer from melanocytes to keratinocytes reducing visible pigmentation, anti-inflammatory effects decreasing post-inflammatory hyperpigmentation from rubbing or allergies, and barrier strengthening improving overall skin health and resilience

[1] Cell Line:Senescent Leydig cells Concentration:25 mM Incubation Time:3 days Result:The apoptosis rate increased from 10% to 27%

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