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Ultimately, it took the confluence of cellular pathology, animal experimentation, and research into chemicals commonly found in both filtered and unfiltered cigarettes for the government to take action

Open comedones: Open comedones, which can also be called blackheads, develop when the blockage is exposed to air

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The industry directly financed extensive promotion of the first article and put into circulation more than a million reprints of it. Some 600,000 of the reprints were sent out to professional people in the name of the editors of a presumably un-biased and unfettered national magazine Life Cancer Article sent to RJR Holders News article The Tobacco Leaf July 28, 1962 The RJ Reynolds Tobacco Company has mailed to its stockholders reprints of the article New Evidence that Cancer May Be Infectious, which appeared in the June 22 issue