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Copper deficiency presents with anemia, leukopenia, muscle weakness, fatigue, altered pigmentation of both skin and hair, impaired immune function, alterations in bone and blood vessel/connective tissue, alterations in cholesterol metabolism, and cognitive deficits

Since glutaminase 1 (GLS1), a key mitochondrial enzyme that catalyzes the deamidation of glutamine, was first discovered in the kidney in 1958 9 , many enzymes involved in glutamine metabolism have been reported 4