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We found that (i) lactate transport is critically involved in the neuroprotective effect mediated by neuronal activation in hypoxia, (ii) lactate supplemented in the culture medium had a neuroprotective effect, and (iii) astrocyte stimulation with consequent release of lactate was associated with neuroprotection

This demonstrates the critical role of the CHAC2-NRF2 signaling pathway in protecting against oxidative stress and highlights CHAC2 as a potential therapeutic target for mitigating APAP-induced liver damage (Zhai et al., 2022)

A liposome analysis of ferroptosis cells found that the accumulation of oxygenated AA-containing phosphatidylethanolamine species was associated with ALOX15 (78), which can shape adaptive immune response by inhibiting dendritic cell maturation and T cell helper cell 17 (TH17) differentiation via activating transcription factor NRF2 (79)

It helps to minimise the impact of free radicals